| Pair Name | Curcumin, Dactolisib | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Dactolisib (PubChem CID: 11977753 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Dactolisib | |||
| Disease Info | [ICD-11: 2D11] | Neuroblastoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP7 | hsa840 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens (Human) | CVCL_0019 |
| Result | Synergistic anti-proliferative and apoptotic effect of NVP-BEZ235 and curcumin on human SH-SY5Y neuroblastoma cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic anti-proliferative and apoptotic effect of NVP-BEZ235 and curcumin on human SH-SY5Y neuroblastoma cells. Med Oncol. 2023 Dec 10;41(1):11. doi: 10.1007/s12032-023-02239-8. | Click |
